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Mutagenicity, insecticidal and trypanocidal activity of some Paraguayan Asteraceae

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dc.contributor.author Rojas de Arias, Antonia
dc.contributor.author Ferro, E
dc.contributor.author Inchausti, Alba
dc.contributor.author Ascurra, M
dc.contributor.author Acosta, N
dc.contributor.author Rodriguez, E
dc.contributor.author Fournet, Alain
dc.date.accessioned 2017-01-07T20:53:37Z
dc.date.available 2017-01-07T20:53:37Z
dc.date.issued 1995
dc.identifier.uri http://localhost:8080/xmlui-directorioacademico/handle/123456789/70
dc.description.abstract The insecticidal, moulting inhibition and trypanocidal effects of crude extracts of 7 Paraguayan Asteraceae were evaluated on Triatoma infestans and bloodstream forms of Trypanosoma cruzi, respectively. Both mutagenicity and toxicity were evaluated by sister chromatid exchange (SCE) in human peripheral lymphocyte culture and by the lethality test of Artemia salina. The ethanolic extracts from Chromolaena christieana (stem and bark), Achyrocline satureoides (leaves and flowers) and Mikania cordifolia (root and stem), at a concentration of 250 μg/ml, showed the highest percentage of lysis on bloodstream forms of Trypanosoma cruzi. The extracts of Chromolaena christieana and Achyrocline satureoides also presented high mutagenic and toxic capacity when they were evaluated by the SCEs assay and Artemia salina test, respectively. Insecticidal activity was only observed in the hexane extract of flowers of Achyrocline satureoides (45% of mortality), when 0.05 μg of crude concentration was applied on Triatoma infestans. The ethanolic extracts of stem from Mikania cordifolia and Vernonia brasiliana inhibited the moulting of Triatoma infestans when it was compared with their controls. Since no ethnobotanical information on these plants has been found related to similar use in Paraguay, our findings suggest, for the first time, the potential anti-trypanocidal and moulting inhibition of these Asteraceae.
dc.format application/pdf
dc.source Journal of Ethnopharmacology
dc.subject Asteraceae
dc.subject Trypanosoma cruzi
dc.subject Trypomastigote forms
dc.subject Triatoma infestans
dc.subject Insecticide
dc.subject Paraguay
dc.subject.mesh Animals
dc.subject.mesh Artemia
dc.subject.mesh Chagas Disease/blood
dc.subject.mesh Chagas Disease/drug therapy
dc.subject.mesh Chagas Disease/parasitology
dc.subject.mesh Humans
dc.subject.mesh Insecticides/isolation & purification
dc.subject.mesh Insecticides/toxicity
dc.subject.mesh Lymphocytes/drug effects
dc.subject.mesh Lymphocytes/ultrastructure
dc.subject.mesh Mice
dc.subject.mesh Mutagenicity Tests
dc.subject.mesh Mutagens/isolation & purification
dc.subject.mesh Mutagens/toxicity
dc.subject.mesh Paraguay
dc.subject.mesh Plant Extracts/pharmacology
dc.subject.mesh Plant Extracts/toxicity
dc.subject.mesh Plants, Medicinal/chemistry
dc.subject.mesh Sister Chromatid Exchange/drug effects
dc.subject.mesh Trypanocidal Agents/isolation & purification
dc.subject.mesh Trypanocidal Agents/toxicity
dc.subject.mesh Trypanosoma cruzi
dc.title Mutagenicity, insecticidal and trypanocidal activity of some Paraguayan Asteraceae
dc.type Artículo
dcterms.bibliographicCitation Journal of Ethnopharmacology 45([S.N]), 35 - 41. 1995
dc.source.volume 45
dc.source.volume [S.N]
dc.source.pages 35 - 41
dc.contributor.identifier 1261551
dc.contributor.identifier 444503
dc.contributor.identifier 562175
dc.contributor.identifier 588790
dc.contributor.identifier 3448193
dc.identifier.doi https://doi.org/10.1016/0378-8741(94)01193-4

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