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Anti-Trypanosoma cruzi and cytotoxic activities of Eugenia uniflora L.

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dc.contributor.author Rojas de Arias, Antonieta
dc.contributor.author Rolón, Miriam
dc.contributor.author Vega, Celeste
dc.contributor.author Santos, Karla K.A.
dc.contributor.author Matias, Edinardo F. F.
dc.contributor.author Tintino, Saulo R.
dc.contributor.author Souza, Celestina E. S.
dc.contributor.author Braga, María F. B. M.
dc.contributor.author Guedes, Gláucia M. M.
dc.contributor.author Costa, José G. M.
dc.contributor.author Menezes, Irwin R. A.
dc.contributor.author Coutinho, Henrique D. M.
dc.date.accessioned 2017-01-07T20:53:25Z
dc.date.available 2017-01-07T20:53:25Z
dc.date.issued 2012
dc.identifier.uri http://localhost:8080/xmlui-directorioacademico/handle/123456789/12
dc.description.abstract Chagas disease is caused by Trypanosoma cruzi, being considered a public health problem. An alternative to combat this pathogen is the use of natural products isolated from fruits such as Eugenia uniflora, a plant used by traditional communities as food and medicine due to its antimicrobial and biological activities. Ethanolic extract from E. uniflora was used to evaluate in vitro anti-epimastigote and cytotoxic activity. This is the first record of anti-Trypanosoma activity of E. uniflora, demonstrating that a concentration presenting 50% of activity (EC(50)) was 62.76 μg/mL. Minimum inhibitory concentration (MIC) was ≤ 1024 μg/mL. Our results indicate that E. uniflora could be a source of plant-derived natural products with anti-epimastigote activity with low toxicity.
dc.format application/pdf
dc.source Experimental Parasitology
dc.subject Chagas disease
dc.subject Eugenia uniflora
dc.subject Antiepimastigote activity
dc.subject Cytotoxicity
dc.subject Trypanosoma cruzi
dc.subject.mesh Animals
dc.subject.mesh Cell Line
dc.subject.mesh Cell Survival/drug effects
dc.subject.mesh Colorimetry
dc.subject.mesh Macrophages/cytology
dc.subject.mesh Macrophages/drug effects
dc.subject.mesh Mice
dc.subject.mesh Plant Extracts/pharmacology
dc.subject.mesh Syzygium/chemistry
dc.subject.mesh Trypanosoma cruzi/drug effects
dc.title Anti-Trypanosoma cruzi and cytotoxic activities of Eugenia uniflora L.
dc.type Artículo
dcterms.bibliographicCitation Experimental Parasitology 131(1), 130 - 132. 2012
dc.source.volume 131
dc.source.number 1
dc.source.pages 130 - 132
dc.contributor.identifier 1261551
dc.contributor.identifier 2270413
dc.contributor.identifier 2098807
dc.identifier.doi 10.1016/j.exppara.2012.02.019
dc.directorio.index MEDLINE

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